› 6p7h

X-ray diffraction
1.78Å resolution

Vaccine-elicited NHP FP-targeting neutralizing antibody DF2F-b.04 in complex with HIV fusion peptide (residue 512-519)

Released:
DOI: 10.2210/pdb6p7h/pdb
PDB entry 6p7h coloured by chain, front view.
PDB entry 6p7h coloured by chain, side view.
PDB entry 6p7h coloured by chain, top view.
Source organisms:
Entry authors: Xu K, Liu K, Wang Y, Kwong PD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209078 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody DF2F-b.04 light chain Chain: B
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 23.9 KDa
Source organism: Platyrrhini
Expression system: Homo sapiens
Antibody DF2F-b.04 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 24.17 KDa
Source organism: Platyrrhini
Expression system: Homo sapiens
Transmembrane protein gp41 Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 733 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 512-519; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 59.164Å b: 62.219Å c: 136.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.23
Expression systems:
  • Homo sapiens
  • Not provided

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