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Crystal structure of CDK4 in complex with CyclinD1 and P21

X-ray diffraction
3.19Å resolution
PDB entry 6p8h coloured by chain, front view.
PDB entry 6p8h coloured by chain, side view.
PDB entry 6p8h coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin D1-CDK4 complex and Cyclin-dependent kinase inhibitor 1
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Multimeric state: hetero trimer
Accessible surface area: 25971.29 Å2
Buried surface area: 5943.13 Å2
Dissociation area: 1,850.56 Å2
Dissociation energy (ΔGdiss): 22.99 kcal/mol
Dissociation entropy (TΔSdiss): 13.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145930

Macromolecules

G1/S-specific cyclin-D1
Chain: A
Length: 249 amino acids
Theoretical weight: 28.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24385 (Residues: 19-267; Coverage: 84%)
Gene names: BCL1, CCND1, PRAD1
Pfam:
InterPro:
G1/S-specific cyclin-D1 in PDB entry 6p8h, assembly 1, front view.
G1/S-specific cyclin-D1 in PDB entry 6p8h, assembly 1, side view.
G1/S-specific cyclin-D1 in PDB entry 6p8h, assembly 1, top view.
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Cyclin-dependent kinase 4
Chain: B
Length: 302 amino acids
Theoretical weight: 33.95 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 2-303; Coverage: 99%)
  • Best match: P11802-2 (Residues: 1-183)
Gene name: CDK4
Pfam: Protein kinase domain
InterPro:
Cyclin-dependent kinase 4 in PDB entry 6p8h, assembly 1, front view.
Cyclin-dependent kinase 4 in PDB entry 6p8h, assembly 1, side view.
Cyclin-dependent kinase 4 in PDB entry 6p8h, assembly 1, top view.
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Cyclin-dependent kinase inhibitor 1
Chain: C
Length: 80 amino acids
Theoretical weight: 9.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P38936 (Residues: 9-85; Coverage: 47%)
Gene names: CAP20, CDKN1, CDKN1A, CIP1, MDA6, PIC1, SDI1, WAF1
Pfam: Cyclin-dependent kinase inhibitor
InterPro:
Cyclin-dependent kinase inhibitor 1 in PDB entry 6p8h, assembly 1, front view.
Cyclin-dependent kinase inhibitor 1 in PDB entry 6p8h, assembly 1, side view.
Cyclin-dependent kinase inhibitor 1 in PDB entry 6p8h, assembly 1, top view.
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