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CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS

X-ray diffraction
2.5Å resolution
PDB entry 6pax coloured by chain, front view.
PDB entry 6pax coloured by chain, side view.
PDB entry 6pax coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Paired box protein Pax-6 and DNA
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Multimeric state: hetero trimer
Accessible surface area: 14849.4 Å2
Buried surface area: 6054.33 Å2
Dissociation area: 2,045.6 Å2
Dissociation energy (ΔGdiss): 19.47 kcal/mol
Dissociation entropy (TΔSdiss): 12.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-120445

Macromolecules

Paired box protein Pax-6
Chain: A
Length: 133 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26367 (Residues: 4-136; Coverage: 32%)
Gene names: AN2, PAX6
Pfam: 'Paired box' domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
SCOP: Paired domain
Paired box protein Pax-6 in PDB entry 6pax, assembly 1, front view.
Paired box protein Pax-6 in PDB entry 6pax, assembly 1, side view.
Paired box protein Pax-6 in PDB entry 6pax, assembly 1, top view.
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DNA chain B
Name: 26 NUCLEOTIDE DNA
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 26 nucleotides
Theoretical weight: 8 KDa
26 NUCLEOTIDE DNA in PDB entry 6pax, assembly 1, front view.
26 NUCLEOTIDE DNA in PDB entry 6pax, assembly 1, side view.
26 NUCLEOTIDE DNA in PDB entry 6pax, assembly 1, top view.
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DNA chain C
Name: 26 NUCLEOTIDE DNA
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 26 nucleotides
Theoretical weight: 7.98 KDa
26 NUCLEOTIDE DNA in PDB entry 6pax, assembly 1, front view.
26 NUCLEOTIDE DNA in PDB entry 6pax, assembly 1, side view.
26 NUCLEOTIDE DNA in PDB entry 6pax, assembly 1, top view.
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