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Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-5 (WK-25)

X-ray diffraction
1.87Å resolution
PDB entry 6pix coloured by chain, front view.
PDB entry 6pix coloured by chain, side view.
PDB entry 6pix coloured by chain, top view.
Source organism: Hepacivirus hominis
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptidase S29 domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 9449.7 Å2
Buried surface area: 313.03 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-100993

Macromolecules

Peptidase S29 domain-containing protein
Chain: A
Length: 220 amino acids
Theoretical weight: 23.35 KDa
Source organism: Hepacivirus hominis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0B4WYC6 (Residues: 4-182; Coverage: 98%)
Pfam: Hepatitis C virus NS3 protease
InterPro:
NS3 protease in PDB entry 6pix, assembly 1, front view.
NS3 protease in PDB entry 6pix, assembly 1, side view.
NS3 protease in PDB entry 6pix, assembly 1, top view.
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