Function and Biology

Cryo-EM structure of AdnA(D934A)-AdnB(D1014A) in complex with AMPPNP

Source organism: Mycolicibacterium smegmatis
Biochemical function: 3'-5' DNA helicase activity
Biological process: DNA duplex unwinding
Cellular component: DNA helicase complex

Sequence families

Pfam Protein families (Pfam)
PF13361
Domain description: UvrD-like helicase C-terminal domain
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
The deposited structure of PDB entry 6ppj contains 2 copies of Pfam domain PF13361 (UvrD-like helicase C-terminal domain) in DNA 3'-5' helicase. Showing 2 copies in chain A [auth B].
The deposited structure of PDB entry 6ppj contains 1 copy of Pfam domain PF13361 (UvrD-like helicase C-terminal domain) in DNA 3'-5' helicase. Showing 1 copy in chain B [auth A].

PF12705
Domain description: PD-(D/E)XK nuclease superfamily
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
The deposited structure of PDB entry 6ppj contains 1 copy of Pfam domain PF12705 (PD-(D/E)XK nuclease superfamily) in DNA 3'-5' helicase. Showing 1 copy in chain A [auth B].
The deposited structure of PDB entry 6ppj contains 1 copy of Pfam domain PF12705 (PD-(D/E)XK nuclease superfamily) in DNA 3'-5' helicase. Showing 1 copy in chain B [auth A].

PF00580
Domain description: UvrD/REP helicase N-terminal domain
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
The deposited structure of PDB entry 6ppj contains 1 copy of Pfam domain PF00580 (UvrD/REP helicase N-terminal domain) in DNA 3'-5' helicase. Showing 1 copy in chain A [auth B].
The deposited structure of PDB entry 6ppj contains 1 copy of Pfam domain PF00580 (UvrD/REP helicase N-terminal domain) in DNA 3'-5' helicase. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
IPR014017
Domain description: UvrD-like DNA helicase, C-terminal
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
IPR014016
Domain description: UvrD-like helicase, ATP-binding domain
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
IPR038726
Domain description: PD-(D/E)XK endonuclease-like domain, AddAB-type
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
IPR011604
Domain description: PD-(D/E)XK endonuclease-like domain superfamily
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
IPR013986
Domain description: DExx box DNA helicase domain superfamily
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase
IPR000212
Domain description: DNA helicase, UvrD/REP type
Occurring in:
  1. DNA 3'-5' helicase
  2. DNA 3'-5' helicase