EC 3.6.4.12: DNA helicase
Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
- 3' to 5' DNA helicase
- 3'-5' DNA helicase
- 3'-5' PfDH
- 5' to 3' DNA helicase
- AvDH1
- BACH1 helicase
- BLM protein
- BRCA1-associated C-terminal helicase
- BcMCM
- CeWRN-1
- DNA helicase 120
- DNA helicase A
- DNA helicase E
- DNA helicase II
- DNA helicase III
- DNA helicase RECQL5'
- DNA helicase VI
- Dbp9p
- DmRECQ5
- DnaB
- DnaB helicase E1
- HHcsA
- HPif1
- Hel E
- Helicase DnaB
- Helicase HDH IV
- Helicase domain of bacteriophage T7 gene 4 protein helicase
- Hmi1p
- MCM helicase
- MCM protein
- MER3 helicase
- MER3 protein
- MPH1
- PDH120
- PIF1
- PcrA
- PcrA helicase
- PfDH A
- Pfh1p
- UvrD
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain T [auth 2].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_7_2_Pfam_PF17855_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17855 (MCM AAA-lid domain)</span> in <span class='highlight'>DNA replication licensing factor MCM2</span>. Showing 1 copy in chain <span class='highlight'>T [auth 2]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain U [auth 3].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_8_3_Pfam_PF17855_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17855 (MCM AAA-lid domain)</span> in <span class='highlight'>DNA replication licensing factor MCM3</span>. Showing 1 copy in chain <span class='highlight'>U [auth 3]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain V [auth 4].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_9_4_Pfam_PF17855_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17855 (MCM AAA-lid domain)</span> in <span class='highlight'>DNA replication licensing factor MCM4</span>. Showing 1 copy in chain <span class='highlight'>V [auth 4]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17855 (MCM AAA-lid domain) in Minichromosome maintenance protein 5. Showing 1 copy in chain L [auth l].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_10_l_Pfam_PF17855_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17855 (MCM AAA-lid domain)</span> in <span class='highlight'>Minichromosome maintenance protein 5</span>. Showing 1 copy in chain <span class='highlight'>L [auth l]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain M [auth m].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_11_m_Pfam_PF17855_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17855 (MCM AAA-lid domain)</span> in <span class='highlight'>DNA replication licensing factor MCM6</span>. Showing 1 copy in chain <span class='highlight'>M [auth m]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain N [auth n].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_12_n_Pfam_PF17855_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17855 (MCM AAA-lid domain)</span> in <span class='highlight'>DNA replication licensing factor MCM7</span>. Showing 1 copy in chain <span class='highlight'>N [auth n]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain T [auth 2].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_7_2_Pfam_PF00493_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF00493 (MCM P-loop domain)</span> in <span class='highlight'>DNA replication licensing factor MCM2</span>. Showing 1 copy in chain <span class='highlight'>T [auth 2]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain U [auth 3].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_8_3_Pfam_PF00493_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF00493 (MCM P-loop domain)</span> in <span class='highlight'>DNA replication licensing factor MCM3</span>. Showing 1 copy in chain <span class='highlight'>U [auth 3]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain V [auth 4].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_9_4_Pfam_PF00493_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF00493 (MCM P-loop domain)</span> in <span class='highlight'>DNA replication licensing factor MCM4</span>. Showing 1 copy in chain <span class='highlight'>V [auth 4]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF00493 (MCM P-loop domain) in Minichromosome maintenance protein 5. Showing 1 copy in chain L [auth l].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_10_l_Pfam_PF00493_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF00493 (MCM P-loop domain)</span> in <span class='highlight'>Minichromosome maintenance protein 5</span>. Showing 1 copy in chain <span class='highlight'>L [auth l]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain M [auth m].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_11_m_Pfam_PF00493_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF00493 (MCM P-loop domain)</span> in <span class='highlight'>DNA replication licensing factor MCM6</span>. Showing 1 copy in chain <span class='highlight'>M [auth m]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain N [auth n].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_12_n_Pfam_PF00493_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF00493 (MCM P-loop domain)</span> in <span class='highlight'>DNA replication licensing factor MCM7</span>. Showing 1 copy in chain <span class='highlight'>N [auth n]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain T [auth 2].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_7_2_Pfam_PF17207_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17207 (MCM OB domain)</span> in <span class='highlight'>DNA replication licensing factor MCM2</span>. Showing 1 copy in chain <span class='highlight'>T [auth 2]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain U [auth 3].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_8_3_Pfam_PF17207_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17207 (MCM OB domain)</span> in <span class='highlight'>DNA replication licensing factor MCM3</span>. Showing 1 copy in chain <span class='highlight'>U [auth 3]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain V [auth 4].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_9_4_Pfam_PF17207_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17207 (MCM OB domain)</span> in <span class='highlight'>DNA replication licensing factor MCM4</span>. Showing 1 copy in chain <span class='highlight'>V [auth 4]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17207 (MCM OB domain) in Minichromosome maintenance protein 5. Showing 1 copy in chain L [auth l].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_10_l_Pfam_PF17207_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17207 (MCM OB domain)</span> in <span class='highlight'>Minichromosome maintenance protein 5</span>. Showing 1 copy in chain <span class='highlight'>L [auth l]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain M [auth m].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_11_m_Pfam_PF17207_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17207 (MCM OB domain)</span> in <span class='highlight'>DNA replication licensing factor MCM6</span>. Showing 1 copy in chain <span class='highlight'>M [auth m]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain N [auth n].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_12_n_Pfam_PF17207_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF17207 (MCM OB domain)</span> in <span class='highlight'>DNA replication licensing factor MCM7</span>. Showing 1 copy in chain <span class='highlight'>N [auth n]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain T [auth 2].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_7_2_Pfam_PF14551_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF14551 (MCM N-terminal domain)</span> in <span class='highlight'>DNA replication licensing factor MCM2</span>. Showing 1 copy in chain <span class='highlight'>T [auth 2]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain V [auth 4].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_9_4_Pfam_PF14551_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF14551 (MCM N-terminal domain)</span> in <span class='highlight'>DNA replication licensing factor MCM4</span>. Showing 1 copy in chain <span class='highlight'>V [auth 4]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF14551 (MCM N-terminal domain) in Minichromosome maintenance protein 5. Showing 1 copy in chain W [auth 5].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_10_5_Pfam_PF14551_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF14551 (MCM N-terminal domain)</span> in <span class='highlight'>Minichromosome maintenance protein 5</span>. Showing 1 copy in chain <span class='highlight'>W [auth 5]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain X [auth 6].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_11_6_Pfam_PF14551_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF14551 (MCM N-terminal domain)</span> in <span class='highlight'>DNA replication licensing factor MCM6</span>. Showing 1 copy in chain <span class='highlight'>X [auth 6]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain N [auth n].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_12_n_Pfam_PF14551_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF14551 (MCM N-terminal domain)</span> in <span class='highlight'>DNA replication licensing factor MCM7</span>. Showing 1 copy in chain <span class='highlight'>N [auth n]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF05916 (GINS complex protein) in DNA replication complex GINS protein PSF1. Showing 1 copy in chain O [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_2_A_Pfam_PF05916_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF05916 (GINS complex protein)</span> in <span class='highlight'>DNA replication complex GINS protein PSF1</span>. Showing 1 copy in chain <span class='highlight'>O [auth A]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF05916 (GINS complex protein) in DNA replication complex GINS protein PSF2. Showing 1 copy in chain P [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_3_B_Pfam_PF05916_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF05916 (GINS complex protein)</span> in <span class='highlight'>DNA replication complex GINS protein PSF2</span>. Showing 1 copy in chain <span class='highlight'>P [auth B]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF05916 (GINS complex protein) in DNA replication complex GINS protein PSF3. Showing 1 copy in chain Q [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_4_C_Pfam_PF05916_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF05916 (GINS complex protein)</span> in <span class='highlight'>DNA replication complex GINS protein PSF3</span>. Showing 1 copy in chain <span class='highlight'>Q [auth C]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF05916 (GINS complex protein) in DNA replication complex GINS protein SLD5. Showing 1 copy in chain R [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_5_D_Pfam_PF05916_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF05916 (GINS complex protein)</span> in <span class='highlight'>DNA replication complex GINS protein SLD5</span>. Showing 1 copy in chain <span class='highlight'>R [auth D]</span>.")
PF20946
Domain description:
DNA polymerase alpha-binding protein Ctf4, C-terminal domain
Occurring in:
Occurring in:
![The deposited structure of PDB entry 6ptn contains 3 copies of Pfam domain PF12341 (Minichromosome loss protein, Mcl1, middle region) in DNA polymerase alpha-binding protein. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_1_F_Pfam_PF12341_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 3 copies of Pfam domain <span class='highlight'>PF12341 (Minichromosome loss protein, Mcl1, middle region)</span> in <span class='highlight'>DNA polymerase alpha-binding protein</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF02724 (CDC45-like protein) in Cell division control protein 45. Showing 1 copy in chain S [auth H].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_6_H_Pfam_PF02724_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF02724 (CDC45-like protein)</span> in <span class='highlight'>Cell division control protein 45</span>. Showing 1 copy in chain <span class='highlight'>S [auth H]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF16922 (DNA replication complex GINS protein SLD5 C-terminus) in DNA replication complex GINS protein SLD5. Showing 1 copy in chain R [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_5_D_Pfam_PF16922_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF16922 (DNA replication complex GINS protein SLD5 C-terminus)</span> in <span class='highlight'>DNA replication complex GINS protein SLD5</span>. Showing 1 copy in chain <span class='highlight'>R [auth D]</span>.")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF18263 (MCM6 C-terminal winged-helix domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain X [auth 6] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_11_6_Pfam_PF18263_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF18263 (MCM6 C-terminal winged-helix domain)</span> in <span class='highlight'>DNA replication licensing factor MCM6</span>. Showing 1 copy in chain <span class='highlight'>X [auth 6]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 6ptn contains 2 copies of Pfam domain PF12619 (Mini-chromosome maintenance protein 2) in DNA replication licensing factor MCM2. Showing 1 copy in chain T [auth 2] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/6ptn_7_2_Pfam_PF12619_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>6ptn</span> contains 2 copies of Pfam domain <span class='highlight'>PF12619 (Mini-chromosome maintenance protein 2)</span> in <span class='highlight'>DNA replication licensing factor MCM2</span>. Showing 1 copy in chain <span class='highlight'>T [auth 2]</span> (this domain is out of the observed residue ranges!).")
InterPro annotations