› › Structure analysis

Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome

Electron Microscopy
4.4Å resolution
PDB entry 6pww coloured by chain, front view.
PDB entry 6pww coloured by chain, side view.
PDB entry 6pww coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tridecamer (preferred)
Entry contents: 7 distinct polypeptide molecules
2 distinct DNA molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tridecamer
Accessible surface area: 103561.0 Å2
Buried surface area: 59460.61 Å2
Dissociation area: 1,984.74 Å2
Dissociation energy (ΔGdiss): -20.88 kcal/mol
Dissociation entropy (TΔSdiss): 41.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-120471

Macromolecules

Retinoblastoma-binding protein 5
Chain: A
Length: 538 amino acids
Theoretical weight: 59.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15291 (Residues: 2-538; Coverage: 100%)
Gene names: RBBP5, RBQ3
Pfam: WD domain, G-beta repeat
InterPro:
Retinoblastoma-binding protein 5 in PDB entry 6pww, assembly 1, front view.
Retinoblastoma-binding protein 5 in PDB entry 6pww, assembly 1, side view.
Retinoblastoma-binding protein 5 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q15291  
153850100150200250300350400450500
 
200400
UniProt
Q15291
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Molecule details ›

Search similar proteins

WD repeat-containing protein 5
Chain: B
Length: 313 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
WD repeat-containing protein 5 in PDB entry 6pww, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 6pww, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61964  
131320406080100120140160180200220240260280300
 
100200300
UniProt
P61964
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Molecule details ›

Search similar proteins

MLL cleavage product C180
Chain: C
Length: 209 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03164 (Residues: 3762-3969; Coverage: 5%)
Gene names: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
Pfam: SET domain
InterPro:
MLL cleavage product C180 in PDB entry 6pww, assembly 1, front view.
MLL cleavage product C180 in PDB entry 6pww, assembly 1, side view.
MLL cleavage product C180 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q03164  
120920406080100120140160180200
 
50100150200
UniProt
Q03164
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Molecule details ›

Search similar proteins

Histone H3.2
Chains: G, K
Length: 136 amino acids
Theoretical weight: 15.44 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P84233 (Residues: 1-136; Coverage: 100%)
Pfam: Core histone H2A/H2B/H3/H4
InterPro:
Histone H3.2 in PDB entry 6pww, assembly 1, front view.
Histone H3.2 in PDB entry 6pww, assembly 1, side view.
Histone H3.2 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P84233  
1136102030405060708090100110120130
 
50100
UniProt
P84233
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Molecule details ›

Search similar proteins

Histone H4
Chains: H, L
Length: 103 amino acids
Theoretical weight: 11.39 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P62799 (Residues: 1-103; Coverage: 100%)
Pfam: Centromere kinetochore component CENP-T histone fold
InterPro:
Histone H4 in PDB entry 6pww, assembly 1, front view.
Histone H4 in PDB entry 6pww, assembly 1, side view.
Histone H4 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P62799  
1103102030405060708090100
 
50100MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
UniProt
P62799
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Molecule details ›

Search similar proteins

Histone H2A type 1
Chains: I, M
Length: 129 amino acids
Theoretical weight: 13.98 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P06897 (Residues: 2-130; Coverage: 99%)
Pfam:
InterPro:
Histone H2A type 1 in PDB entry 6pww, assembly 1, front view.
Histone H2A type 1 in PDB entry 6pww, assembly 1, side view.
Histone H2A type 1 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P06897  
1129102030405060708090100110120
 
50100
UniProt
P06897
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Molecule details ›

Search similar proteins

Histone H2B 1.1
Chains: J, N
Length: 123 amino acids
Theoretical weight: 13.66 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P02281 (Residues: 5-126; Coverage: 97%)
Pfam: Core histone H2A/H2B/H3/H4
InterPro:
Histone H2B 1.1 in PDB entry 6pww, assembly 1, front view.
Histone H2B 1.1 in PDB entry 6pww, assembly 1, side view.
Histone H2B 1.1 in PDB entry 6pww, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P02281  
1123102030405060708090100110120
 
50100
UniProt
P02281
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Molecule details ›

Search similar proteins

DNA chain O
Name: DNA (146-MER)
Representative chains: O
Length: 147 nucleotides
Theoretical weight: 45.14 KDa
DNA (146-MER) in PDB entry 6pww, assembly 1, front view.
DNA (146-MER) in PDB entry 6pww, assembly 1, side view.
DNA (146-MER) in PDB entry 6pww, assembly 1, top view.
Loading Protvista...
Molecule details ›

Search similar DNA

DNA chain P
Name: DNA (146-MER)
Representative chains: P
Length: 147 nucleotides
Theoretical weight: 45.61 KDa
DNA (146-MER) in PDB entry 6pww, assembly 1, front view.
DNA (146-MER) in PDB entry 6pww, assembly 1, side view.
DNA (146-MER) in PDB entry 6pww, assembly 1, top view.
Loading Protvista...
Molecule details ›

Search similar DNA

Quick links