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Crystal Structure of human Indoleamine 2,3-Dioxygenase 1 in complex with PF-06840003 in Active Site and Si site

X-ray diffraction
2.65Å resolution
PDB entry 6pz1 coloured by chain, front view.
PDB entry 6pz1 coloured by chain, side view.
PDB entry 6pz1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Indoleamine 2,3-dioxygenase 1
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Multimeric state: monomeric
Accessible surface area: 15878.88 Å2
Buried surface area: 1436.46 Å2
Dissociation area: 107.67 Å2
Dissociation energy (ΔGdiss): 0.14 kcal/mol
Dissociation entropy (TΔSdiss): 0.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147133
Assembly 2
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Assembly Name: Indoleamine 2,3-dioxygenase 1
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Multimeric state: monomeric
Accessible surface area: 16093.74 Å2
Buried surface area: 2130.44 Å2
Dissociation area: 141.49 Å2
Dissociation energy (ΔGdiss): 0.2 kcal/mol
Dissociation entropy (TΔSdiss): 0.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147133

Macromolecules

Indoleamine 2,3-dioxygenase 1
Chains: A, B
Length: 425 amino acids
Theoretical weight: 47.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14902 (Residues: 11-403; Coverage: 98%)
Gene names: IDO, IDO1, INDO
Pfam: Indoleamine 2,3-dioxygenase
InterPro:
Indoleamine 2,3-dioxygenase 1 in PDB entry 6pz1, assembly 1, front view.
Indoleamine 2,3-dioxygenase 1 in PDB entry 6pz1, assembly 1, side view.
Indoleamine 2,3-dioxygenase 1 in PDB entry 6pz1, assembly 1, top view.
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