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Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide

X-ray diffraction
1.615Å resolution
PDB entry 6qdr coloured by chain, front view.
PDB entry 6qdr coloured by chain, side view.
PDB entry 6qdr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 14-3-3 protein sigma and Serine/threonine-protein kinase PAK 6
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Multimeric state: hetero tetramer
Accessible surface area: 23803.99 Å2
Buried surface area: 5365.65 Å2
Dissociation area: 866.3 Å2
Dissociation energy (ΔGdiss): 8.8 kcal/mol
Dissociation entropy (TΔSdiss): 12.18 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152171

Macromolecules

14-3-3 protein sigma
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
InterPro:
14-3-3 protein sigma in PDB entry 6qdr, assembly 1, front view.
14-3-3 protein sigma in PDB entry 6qdr, assembly 1, side view.
14-3-3 protein sigma in PDB entry 6qdr, assembly 1, top view.
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Serine/threonine-protein kinase PAK 6
Chain: B
Length: 12 amino acids
Theoretical weight: 1.3 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NQU5 (Residues: 94-104; Coverage: 2%)
Gene names: PAK5, PAK6
Serine/threonine-protein kinase PAK 6 in PDB entry 6qdr, assembly 1, front view.
Serine/threonine-protein kinase PAK 6 in PDB entry 6qdr, assembly 1, side view.
Serine/threonine-protein kinase PAK 6 in PDB entry 6qdr, assembly 1, top view.
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