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Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (open state)

Electron Microscopy
3.6Å resolution
PDB entry 6qm9 coloured by chain, front view.
PDB entry 6qm9 coloured by chain, side view.
PDB entry 6qm9 coloured by chain, top view.
Source organism: Fusarium vanettenii 77-13-4
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Plasma membrane channel protein
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Multimeric state: homo dimer
Accessible surface area: 65114.08 Å2
Buried surface area: 10032.3 Å2
Dissociation area: 4,836.72 Å2
Dissociation energy (ΔGdiss): 63.6 kcal/mol
Dissociation entropy (TΔSdiss): 16.87 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-111787

Macromolecules

Plasma membrane channel protein
Chains: A, B
Length: 735 amino acids
Theoretical weight: 83.2 KDa
Source organism: Fusarium vanettenii 77-13-4
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: C7Z7K1 (Residues: 1-735; Coverage: 100%)
Gene name: NECHADRAFT_66456
Pfam:
InterPro: Anoctamin
Plasma membrane channel protein in PDB entry 6qm9, assembly 1, front view.
Plasma membrane channel protein in PDB entry 6qm9, assembly 1, side view.
Plasma membrane channel protein in PDB entry 6qm9, assembly 1, top view.
PDBe-KB: UniProt Coverage View: C7Z7K1  
1735100200300400500600700
 
200400600
UniProt
C7Z7K1
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Sequence conservation
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