Structure analysis

Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide

X-ray diffraction
1.96Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 20695.94 Å2
Buried surface area: 1592.41 Å2
Dissociation area: 796.2 Å2
Dissociation energy (ΔGdiss): -0.07 kcal/mol
Dissociation entropy (TΔSdiss): 12.89 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172579
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 20832.2 Å2
Buried surface area: 1613.13 Å2
Dissociation area: 806.57 Å2
Dissociation energy (ΔGdiss): 0.49 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172579

Macromolecules

Chains: A, B, C, D
Length: 251 amino acids
Theoretical weight: 27.55 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q16790 (Residues: 141-391; Coverage: 60%)
Gene names: CA9, G250, MN
Pfam: Eukaryotic-type carbonic anhydrase
InterPro:

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