› 6r2s

X-ray diffraction
3.04Å resolution

The structure of Plasmodium vivax Duffy binding protein (PvDBP) bound to human antibody DB9

Released:
DOI: 10.2210/pdb6r2s/pdb
PDB entry 6r2s coloured by chain, front view.
PDB entry 6r2s coloured by chain, side view.
PDB entry 6r2s coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody.
Rawlinson TA, Barber NM, Mohring F, Cho JS, Kosaisavee V, Gérard SF, Alanine DGW, Labbé GM, Elias SC, Silk SE, Quinkert D, Jin J, Marshall JM, Payne RO, Minassian AM, Russell B, Rénia L, Nosten FH, Moon RW, Higgins MK, Draper SJ
OpenAccess logo Nat Microbiol 4 1497-1507 (2019)
PMID: 31133755

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210859 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody DB9 light chain Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antibody DB9 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 278 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Duffy receptor Chain: C
Molecule details ›
Chain: C
Length: 300 amino acids
Theoretical weight: 35.7 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli
UniProt:
  • Canonical: P22290 (Residues: 211-508; Coverage: 28%)
Gene name: PVDR
Sequence domains: Duffy binding domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6222
Unit cell:
a: 173.56Å b: 173.56Å c: 169.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.238
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

9 review citations

Malaria vaccines since 2000: progress, priorities, products.
Duffy et al. (2020)
8 more

7 mentions without citation

Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion.
Patarroyo et al. (2020)
6 more