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Human DNMT3B PWWP domain in complex with triisopropanolamine

X-ray diffraction
2.269Å resolution
PDB entry 6r3e coloured by chain, front view.
PDB entry 6r3e coloured by chain, side view.
PDB entry 6r3e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA (cytosine-5)-methyltransferase 3B
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Multimeric state: monomeric
Accessible surface area: 7623.18 Å2
Buried surface area: 440.79 Å2
Dissociation area: 67.65 Å2
Dissociation energy (ΔGdiss): 8.53 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193641
Assembly 2
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Assembly Name: DNA (cytosine-5)-methyltransferase 3B
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Multimeric state: monomeric
Accessible surface area: 7598.65 Å2
Buried surface area: 324.53 Å2
Dissociation area: 76.06 Å2
Dissociation energy (ΔGdiss): 10.06 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193641

Macromolecules

DNA (cytosine-5)-methyltransferase 3B
Chains: A, B
Length: 274 amino acids
Theoretical weight: 30.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBC3 (Residues: 215-351; Coverage: 21%)
Gene name: DNMT3B
Pfam: PWWP domain
InterPro: PWWP domain
DNA (cytosine-5)-methyltransferase 3B in PDB entry 6r3e, assembly 1, front view.
DNA (cytosine-5)-methyltransferase 3B in PDB entry 6r3e, assembly 1, side view.
DNA (cytosine-5)-methyltransferase 3B in PDB entry 6r3e, assembly 1, top view.
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