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DPP1 in complex with inhibitor

X-ray diffraction
1.54Å resolution
PDB entry 6rni coloured by chain, front view.
PDB entry 6rni coloured by chain, side view.
PDB entry 6rni coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dipeptidyl peptidase 1 heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 15329.71 Å2
Buried surface area: 11251.41 Å2
Dissociation area: 1,597.59 Å2
Dissociation energy (ΔGdiss): 4.74 kcal/mol
Dissociation entropy (TΔSdiss): 12.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156841

Macromolecules

Dipeptidyl peptidase 1 exclusion domain chain
Chain: A
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 25-143; Coverage: 27%)
Gene names: CPPI, CTSC
Pfam: Cathepsin C exclusion domain
InterPro:
Dipeptidyl peptidase 1 exclusion domain chain in PDB entry 6rni, assembly 1, front view.
Dipeptidyl peptidase 1 exclusion domain chain in PDB entry 6rni, assembly 1, side view.
Dipeptidyl peptidase 1 exclusion domain chain in PDB entry 6rni, assembly 1, top view.
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Dipeptidyl peptidase 1 heavy chain
Chain: B
Length: 166 amino acids
Theoretical weight: 18.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 229-394; Coverage: 38%)
Gene names: CPPI, CTSC
Pfam: Papain family cysteine protease
InterPro:
Dipeptidyl peptidase 1 heavy chain in PDB entry 6rni, assembly 1, front view.
Dipeptidyl peptidase 1 heavy chain in PDB entry 6rni, assembly 1, side view.
Dipeptidyl peptidase 1 heavy chain in PDB entry 6rni, assembly 1, top view.
Molecule details ›

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Dipeptidyl peptidase 1 light chain
Chain: C
Length: 69 amino acids
Theoretical weight: 7.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 395-463; Coverage: 16%)
Gene names: CPPI, CTSC
InterPro:
Dipeptidyl peptidase 1 light chain in PDB entry 6rni, assembly 1, front view.
Dipeptidyl peptidase 1 light chain in PDB entry 6rni, assembly 1, side view.
Dipeptidyl peptidase 1 light chain in PDB entry 6rni, assembly 1, top view.
Molecule details ›

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