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Cryo-EM structure of the activated Drs2p-Cdc50p

Source organisms:
Biochemical function: protein binding
Biological process: aminophospholipid translocation
Cellular component: phospholipid-translocating ATPase complex

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EC 7.6.2.1: P-type phospholipid transporter

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
  • Aminophospholipid-transporting ATPase
  • Flippase
  • Phospholipid-transporting ATPase

EC 7.2.4.2: Oxaloacetate decarboxylase (Na(+) extruding)

Reaction catalysed:
Oxaloacetate + 2 Na(+)(Side 1) = pyruvate + CO(2) + 2 Na(+)(Side 2)
Systematic name:
Oxaloacetate carboxy-lyase (pyruvate-forming; Na(+)-extruding)
Alternative Name(s):
  • Oxalacetic acid decarboxylase
  • Oxalate beta-decarboxylase
  • Oxaloacetate beta-decarboxylase
  • Oxaloacetate carboxy-lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03381
Domain description: LEM3 (ligand-effect modulator 3) family / CDC50 family
Occurring in:
  1. Phospholipid-transporting ATPase accessory subunit CDC50
The deposited structure of PDB entry 6roj contains 1 copy of Pfam domain PF03381 (LEM3 (ligand-effect modulator 3) family / CDC50 family) in Phospholipid-transporting ATPase accessory subunit CDC50. Showing 1 copy in chain B [auth C].

PF00364
Domain description: Biotin-requiring enzyme
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
The deposited structure of PDB entry 6roj contains 1 copy of Pfam domain PF00364 (Biotin-requiring enzyme) in Oxaloacetate decarboxylase alpha chain. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF16212
Domain description: Phospholipid-translocating P-type ATPase C-terminal
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
The deposited structure of PDB entry 6roj contains 1 copy of Pfam domain PF16212 (Phospholipid-translocating P-type ATPase C-terminal) in Oxaloacetate decarboxylase alpha chain. Showing 1 copy in chain A.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
The deposited structure of PDB entry 6roj contains 1 copy of Pfam domain PF13246 (Cation transport ATPase (P-type)) in Oxaloacetate decarboxylase alpha chain. Showing 1 copy in chain A.

PF16209
Domain description: Phospholipid-translocating ATPase N-terminal
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
The deposited structure of PDB entry 6roj contains 1 copy of Pfam domain PF16209 (Phospholipid-translocating ATPase N-terminal) in Oxaloacetate decarboxylase alpha chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005045
Domain description: CDC50/LEM3 family
Occurring in:
  1. Phospholipid-transporting ATPase accessory subunit CDC50
IPR000089
Domain description: Biotin/lipoyl attachment
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR023299
Domain description: P-type ATPase, cytoplasmic domain N
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR001882
Domain description: Biotin-binding site
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR011053
Domain description: Single hybrid motif
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR032630
Domain description: P-type ATPase, C-terminal
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR001757
Domain description: P-type ATPase
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR018303
Domain description: P-type ATPase, phosphorylation site
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR044492
Domain description: P-type ATPase, haloacid dehalogenase domain
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR008250
Domain description: P-type ATPase, A domain superfamily
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR023298
Domain description: P-type ATPase, transmembrane domain superfamily
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR006539
Domain description: P-type ATPase, subfamily IV
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2
IPR032631
Domain description: P-type ATPase, N-terminal
Occurring in:
  1. Oxaloacetate decarboxylase alpha chain; Phospholipid-transporting ATPase DRS2

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