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X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with aptamer A9g

X-ray diffraction
2.2Å resolution
PDB entry 6rti coloured by chain, front view.
PDB entry 6rti coloured by chain, side view.
PDB entry 6rti coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutamate carboxypeptidase 2 and RNA
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Multimeric state: hetero tetramer
Accessible surface area: 60379.21 Å2
Buried surface area: 25438.89 Å2
Dissociation area: 2,958.87 Å2
Dissociation energy (ΔGdiss): 21.21 kcal/mol
Dissociation entropy (TΔSdiss): 16.24 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170043

Macromolecules

Glutamate carboxypeptidase 2
Chain: A
Length: 707 amino acids
Theoretical weight: 79.61 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q04609 (Residues: 44-750; Coverage: 94%)
Gene names: FOLH, FOLH1, GIG27, NAALAD1, PSM, PSMA
Pfam:
InterPro:
Glutamate carboxypeptidase 2 in PDB entry 6rti, assembly 1, front view.
Glutamate carboxypeptidase 2 in PDB entry 6rti, assembly 1, side view.
Glutamate carboxypeptidase 2 in PDB entry 6rti, assembly 1, top view.
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RNA chain X
Name: Aptamer A9g, RNA (43-MER)
Representative chains: X
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 43 nucleotides
Theoretical weight: 13.76 KDa
Aptamer A9g, RNA (43-MER) in PDB entry 6rti, assembly 1, front view.
Aptamer A9g, RNA (43-MER) in PDB entry 6rti, assembly 1, side view.
Aptamer A9g, RNA (43-MER) in PDB entry 6rti, assembly 1, top view.
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