› › Structure analysis

Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)3-hydroxy-Leu peptide

X-ray diffraction
2.42Å resolution
PDB entry 6ruj coloured by chain, front view.
PDB entry 6ruj coloured by chain, side view.
PDB entry 6ruj coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Hypoxia-inducible factor 1-alpha inhibitor and peptide
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 31581.02 Å2
Buried surface area: 9290.31 Å2
Dissociation area: 1,900.26 Å2
Dissociation energy (ΔGdiss): 30.4 kcal/mol
Dissociation entropy (TΔSdiss): 14.1 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-167418

Macromolecules

Hypoxia-inducible factor 1-alpha inhibitor
Chain: A
Length: 349 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NWT6 (Residues: 1-349; Coverage: 100%)
Gene names: FIH1, HIF1AN
Pfam: Cupin-like domain
InterPro:
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 6ruj, assembly 1, front view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 6ruj, assembly 1, side view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 6ruj, assembly 1, top view.
Molecule details ›

Search similar proteins

CONSENSUS ANKYRIN REPEAT DOMAIN-(D)3-hydroxy-Leu
Chain: B
Length: 15 amino acids
Theoretical weight: 1.62 KDa
Source organism: synthetic construct
Expression system: Not provided
InterPro: Ankyrin repeat
CONSENSUS ANKYRIN REPEAT DOMAIN-(D)3-hydroxy-Leu in PDB entry 6ruj, assembly 1, front view.
CONSENSUS ANKYRIN REPEAT DOMAIN-(D)3-hydroxy-Leu in PDB entry 6ruj, assembly 1, side view.
CONSENSUS ANKYRIN REPEAT DOMAIN-(D)3-hydroxy-Leu in PDB entry 6ruj, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links