6sbu

X-ray diffraction
2.91Å resolution

X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-132412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase A chain Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 332 amino acids
Theoretical weight: 36.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00338 (Residues: 2-332; Coverage: 100%)
Gene names: LDHA, PIG19
Sequence domains:

Ligands and Environments


Cofactor: Ligand NAI 2 x NAI
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 78.445Å b: 143.853Å c: 311.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.244
Expression system: Escherichia coli BL21(DE3)