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X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3)

Source organism: Homo sapiens
Biochemical function: cadherin binding
Biological process: carboxylic acid metabolic process
Cellular component: oxidoreductase complex

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EC 1.1.1.27: L-lactate dehydrogenase

Reaction catalysed:
(S)-lactate + NAD(+) = pyruvate + NADH
Systematic name:
(S)-lactate:NAD(+) oxidoreductase
Alternative Name(s):
  • L(+)-nLDH
  • L-(+)-lactate dehydrogenase
  • L-lactic acid dehydrogenase
  • L-lactic dehydrogenase
  • Lactate dehydrogenase
  • Lactate dehydrogenase NAD-dependent
  • Lactic acid dehydrogenase
  • Lactic dehydrogenase
  • NAD-lactate dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02866
Domain description: lactate/malate dehydrogenase, alpha/beta C-terminal domain
Occurring in:
  1. L-lactate dehydrogenase A chain
The deposited structure of PDB entry 6sbu contains 8 copies of Pfam domain PF02866 (lactate/malate dehydrogenase, alpha/beta C-terminal domain) in L-lactate dehydrogenase A chain. Showing 1 copy in chain A.

PF00056
Domain description: lactate/malate dehydrogenase, NAD binding domain
Occurring in:
  1. L-lactate dehydrogenase A chain
The deposited structure of PDB entry 6sbu contains 8 copies of Pfam domain PF00056 (lactate/malate dehydrogenase, NAD binding domain) in L-lactate dehydrogenase A chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001557
Domain description: L-lactate/malate dehydrogenase
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR015955
Domain description: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR011304
Domain description: L-lactate dehydrogenase
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR018177
Domain description: L-lactate dehydrogenase, active site
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR022383
Domain description: Lactate/malate dehydrogenase, C-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR001236
Domain description: Lactate/malate dehydrogenase, N-terminal
Occurring in:
  1. L-lactate dehydrogenase A chain
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. L-lactate dehydrogenase A chain

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