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Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,8)

Electron Microscopy
4.5Å resolution
PDB entry 6skn coloured by chain, front view.
PDB entry 6skn coloured by chain, side view.
PDB entry 6skn coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo octadecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: homo octadecamer
Accessible surface area: 205481.72 Å2
Buried surface area: 38727.2 Å2
Dissociation area: 1,550.96 Å2
Dissociation energy (ΔGdiss): -9.21 kcal/mol
Dissociation entropy (TΔSdiss): 31.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-238688

Macromolecules

Capsid protein p24
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 231 amino acids
Theoretical weight: 25.61 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 133-363; Coverage: 16%)
Gene name: gag-pol
Pfam: Gag protein p24 C-terminal domain
InterPro:
Capsid protein p24 in PDB entry 6skn, assembly 1, front view.
Capsid protein p24 in PDB entry 6skn, assembly 1, side view.
Capsid protein p24 in PDB entry 6skn, assembly 1, top view.
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