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Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.

Acton O, Grant T, Nicastro G, Ball NJ, Goldstone DC, Robertson LE, Sader K, Nans A, Ramos A, Stoye JP, Taylor IA, Rosenthal PB
Nat Commun 10 5822 (2019)
Related entries: 6sa9, 6sai, 6ssk, 6ssl, 6ssm

Cited: 13 times
EuropePMC logo PMID: 31862888

Abstract

The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores.

Articles - 6ssj mentioned but not cited (1)

  1. Viral Phrenology. Wilson DP, Roof DA. Viruses 13 2191 (2021)


Reviews citing this publication (2)

  1. Viral vector-based gene therapies in the clinic. Zhao Z, Anselmo AC, Mitragotri S. Bioeng Transl Med 7 e10258 (2022)
  2. Structural Analysis of Retrovirus Assembly and Maturation. Krebs AS, Mendonça LM, Zhang P. Viruses 14 54 (2021)

Articles citing this publication (10)

  1. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. Obr M, Ricana CL, Nikulin N, Feathers JR, Klanschnig M, Thader A, Johnson MC, Vogt VM, Schur FKM, Dick RA. Nat Commun 12 3226 (2021)
  2. Structural properties and peptide ligand binding of the capsid homology domains of human Arc. Hallin EI, Bramham CR, Kursula P. Biochem Biophys Rep 26 100975 (2021)
  3. Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control. Cottee MA, Beckwith SL, Letham SC, Kim SJ, Young GR, Stoye JP, Garfinkel DJ, Taylor IA. Nat Commun 12 5590 (2021)
  4. A survey of jaagsiekte sheep retrovirus (JSRV) infection in sheep in the three northeastern provinces of China. Shi W, Jia S, Guan X, Yao X, Pan R, Huang X, Ma Y, Wei J, Xu Y. Arch Virol 166 831-840 (2021)
  5. Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM. Highland CM, Tan A, Ricaña CL, Briggs JAG, Dick RA. Proc Natl Acad Sci U S A 120 e2220545120 (2023)
  6. A Comprehensive Analysis of Human Endogenous Retroviruses HERV-K (HML.2) from Teratocarcinoma Cell Lines and Detection of Viral Cargo in Microvesicles. Morozov VA, Morozov AV. Int J Mol Sci 22 12398 (2021)
  7. Molecular architecture and conservation of an immature human endogenous retrovirus. Krebs AS, Liu HF, Zhou Y, Rey JS, Levintov L, Shen J, Howe A, Perilla JR, Bartesaghi A, Zhang P. Nat Commun 14 5149 (2023)
  8. Prolonged activity of HERV-K(HML2) in Old World Monkeys accounts for recent integrations and novel recombinant variants. Chabukswar S, Grandi N, Tramontano E. Front Microbiol 13 1040792 (2022)
  9. Evolutionary conservation of an ancient retroviral gagpol gene in Artiodactyla. Simpson J, Kozak CA, Boso G. J Virol 97 e0053523 (2023)
  10. The Diverse Evolutionary Histories of Domesticated Metaviral Capsid Genes in Mammals. Henriques WS, Young JM, Nemudryi A, Nemudraia A, Wiedenheft B, Malik HS. Mol Biol Evol 41 msae061 (2024)


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