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ERa_L536S (L536S/C381S/C471S,C530S) in complex with a tricyclic indole (compound 6)

X-ray diffraction
1.74Å resolution
PDB entry 6suo coloured by chain, front view.
PDB entry 6suo coloured by chain, side view.
PDB entry 6suo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor
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Multimeric state: homo dimer
Accessible surface area: 18670.7 Å2
Buried surface area: 2514.36 Å2
Dissociation area: 1,257.18 Å2
Dissociation energy (ΔGdiss): 3.07 kcal/mol
Dissociation entropy (TΔSdiss): 12.82 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136919

Macromolecules

Estrogen receptor
Chains: A, B
Length: 252 amino acids
Theoretical weight: 28.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 307-554; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
Estrogen receptor in PDB entry 6suo, assembly 1, front view.
Estrogen receptor in PDB entry 6suo, assembly 1, side view.
Estrogen receptor in PDB entry 6suo, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P03372  
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