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Antibody-anti-idiotype complex: AP33 Fab (hepatitis C virus E2 antibody) - B2.1A scFv (anti-idiotype)

X-ray diffraction
1.85Å resolution
PDB entry 6sxi coloured by chain, front view.
PDB entry 6sxi coloured by chain, side view.
PDB entry 6sxi coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero tetramer
Accessible surface area: 27194.52 Å2
Buried surface area: 7745.5 Å2
Dissociation area: 1,079.11 Å2
Dissociation energy (ΔGdiss): 2.11 kcal/mol
Dissociation entropy (TΔSdiss): 13.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-214196

Macromolecules

Fab heavy chain
Chain: H
Length: 218 amino acids
Theoretical weight: 23.68 KDa
Source organism: Mus musculus
InterPro:
Fab heavy chain in PDB entry 6sxi, assembly 1, front view.
Fab heavy chain in PDB entry 6sxi, assembly 1, side view.
Fab heavy chain in PDB entry 6sxi, assembly 1, top view.
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Fab light chain
Chain: L
Length: 218 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
InterPro:
Fab light chain in PDB entry 6sxi, assembly 1, front view.
Fab light chain in PDB entry 6sxi, assembly 1, side view.
Fab light chain in PDB entry 6sxi, assembly 1, top view.
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Single chain Fv - heavy chain
Chain: A
Length: 119 amino acids
Theoretical weight: 13.37 KDa
Source organism: Mus musculus
InterPro:
Single chain Fv - heavy chain in PDB entry 6sxi, assembly 1, front view.
Single chain Fv - heavy chain in PDB entry 6sxi, assembly 1, side view.
Single chain Fv - heavy chain in PDB entry 6sxi, assembly 1, top view.
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Single chain Fv - light chain
Chain: B
Length: 108 amino acids
Theoretical weight: 11.77 KDa
Source organism: Mus musculus
InterPro:
Single chain Fv - light chain in PDB entry 6sxi, assembly 1, front view.
Single chain Fv - light chain in PDB entry 6sxi, assembly 1, side view.
Single chain Fv - light chain in PDB entry 6sxi, assembly 1, top view.
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