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ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand FM26

X-ray diffraction
1.79Å resolution
PDB entry 6t4j coloured by chain, front view.
PDB entry 6t4j coloured by chain, side view.
PDB entry 6t4j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nuclear receptor ROR-gamma
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Multimeric state: monomeric
Accessible surface area: 12104.71 Å2
Buried surface area: 268.75 Å2
Dissociation area: 134.37 Å2
Dissociation energy (ΔGdiss): 0.89 kcal/mol
Dissociation entropy (TΔSdiss): 0.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156324

Macromolecules

Nuclear receptor ROR-gamma
Chain: A
Length: 263 amino acids
Theoretical weight: 30.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51449 (Residues: 265-507; Coverage: 47%)
Gene names: NR1F3, RORC, RORG, RZRG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
Nuclear receptor ROR-gamma in PDB entry 6t4j, assembly 1, front view.
Nuclear receptor ROR-gamma in PDB entry 6t4j, assembly 1, side view.
Nuclear receptor ROR-gamma in PDB entry 6t4j, assembly 1, top view.
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