› 6t9o

Electron Microscopy
3.39Å resolution

CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(3,5)P2

Released:
DOI: 10.2210/pdb6t9o/pdb
PDB entry 6t9o coloured by chain, front view.
PDB entry 6t9o coloured by chain, side view.
PDB entry 6t9o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP
OpenAccess logo Structure 28 169-184.e5 (2020)
PMID: 31806353
Related structures: EMD-10419

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Polycystin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 547 amino acids
Theoretical weight: 63.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13563 (Residues: 185-723; Coverage: 56%)
Gene names: PKD2, TRPP1, TRPP2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 8 x NAG
Ligand CLR 4 x CLR
Ligand UMQ 20 x UMQ
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.39Å
Relevant EMDB volumes: EMD-10419
Expression system: Spodoptera frugiperda

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Citations

11 review citations

The energetics of protein-lipid interactions as viewed by molecular simulations.
Corey et al. (2020)
10 more

1 mention without citation

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.
Wang et al. (2020)