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Structure of Cerezyme at pH 4.6

X-ray diffraction
1.59Å resolution
PDB entry 6tjj coloured by chain, front view.
PDB entry 6tjj coloured by chain, side view.
PDB entry 6tjj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Lysosomal acid glucosylceramidase
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Multimeric state: monomeric
Accessible surface area: 19566.67 Å2
Buried surface area: 3304.93 Å2
Dissociation area: 115.61 Å2
Dissociation energy (ΔGdiss): -0.43 kcal/mol
Dissociation entropy (TΔSdiss): -0.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137377
Assembly 2 (preferred)
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Assembly Name: Lysosomal acid glucosylceramidase
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Multimeric state: monomeric
Accessible surface area: 19329.55 Å2
Buried surface area: 3529.86 Å2
Dissociation area: 62.96 Å2
Dissociation energy (ΔGdiss): -0.32 kcal/mol
Dissociation entropy (TΔSdiss): -0.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137377

Macromolecules

Lysosomal acid glucosylceramidase
Chains: AAA, BBB
Length: 497 amino acids
Theoretical weight: 55.64 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P04062 (Residues: 40-536; Coverage: 100%)
Gene names: GBA, GBA1, GC, GLUC
Pfam:
InterPro:
Lysosomal acid glucosylceramidase in PDB entry 6tjj, assembly 2, front view.
Lysosomal acid glucosylceramidase in PDB entry 6tjj, assembly 2, side view.
Lysosomal acid glucosylceramidase in PDB entry 6tjj, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P04062  
149750100150200250300350400450
 
200400
UniProt
P04062
Chains
Domains
Ligand binding sites
Molecule details ›

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