› 6tom

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain

Ligands and Environments

2 bound ligands:
Ligand NQZ 1 x NQZ
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6122
Unit cell:
a: 67.279Å b: 67.279Å c: 166.379Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.197 0.218
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Advances in targeting 'undruggable' transcription factors with small molecules.
Henley et al. (2021)
5 more

3 mentions without citation

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
Bellenie et al. (2020)
2 more