› 6tqk

Electron Microscopy
3.35Å resolution

Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament.

Released:
DOI: 10.2210/pdb6tqk/pdb
PDB entry 6tqk coloured by chain, front view.
PDB entry 6tqk coloured by chain, side view.
PDB entry 6tqk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Bokhove M, Han L, Hebert H, Carroni M, Yasumasu S, Rampoldi L, Wu B, Jovine L
OpenAccess logo EMBO J 39 e106807 (2020)
PMID: 33196145
Related structures: EMD-10553

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139838 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Uromodulin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 563 amino acids
Theoretical weight: 61.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07911 (Residues: 25-587; Coverage: 91%)
Gene name: UMOD
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.35Å
Relevant EMDB volumes: EMD-10553

Quick links

Citations

8 review citations

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Bianchi et al. (2020)
7 more

2 mentions without citation

Glycoprotein 2 in health and disease: lifting the veil.
Lin et al. (2021)
1 more