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Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament.

Electron Microscopy
3.35Å resolution
PDB entry 6tqk coloured by chain, front view.
PDB entry 6tqk coloured by chain, side view.
PDB entry 6tqk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Uromodulin
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Multimeric state: homo trimer
Accessible surface area: 36420.76 Å2
Buried surface area: 14540.22 Å2
Dissociation area: 2,815.13 Å2
Dissociation energy (ΔGdiss): 27.04 kcal/mol
Dissociation entropy (TΔSdiss): 13.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139838

Macromolecules

Uromodulin
Chains: A, B, C
Length: 563 amino acids
Theoretical weight: 61.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07911 (Residues: 25-587; Coverage: 91%)
Gene name: UMOD
Pfam:
InterPro:
Uromodulin in PDB entry 6tqk, assembly 1, front view.
Uromodulin in PDB entry 6tqk, assembly 1, side view.
Uromodulin in PDB entry 6tqk, assembly 1, top view.
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