› 6tzy

X-ray diffraction
3Å resolution

Crystal Structure of a lipin/Pah Phosphatidic Acid Phosphatase

Released:
DOI: 10.2210/pdb6tzy/pdb
PDB entry 6tzy coloured by chain, front view.
PDB entry 6tzy coloured by chain, side view.
PDB entry 6tzy coloured by chain, top view.
Source organism: Tetrahymena thermophila
Primary publication:
Crystal Structure of a lipin/Pah Phosphatidic Acid Phosphatase
Khayyo VI, Hoffmann RM, Wang H, Bell JA, Burke JE, Reue K, Airola MV
Nat Commun 11 1309- (2020)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LNS2/PITP domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 321 amino acids
Theoretical weight: 36.73 KDa
Source organism: Tetrahymena thermophila
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: I7MFJ3 (Residues: 1-321; Coverage: 96%)
Gene name: TTHERM_00215970
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 5 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-2
Spacegroup: C2
Unit cell:
a: 108.017Å b: 135.126Å c: 90.974Å
α: 90° β: 116.19° γ: 90°
R-values:
R R work R free
0.238 0.237 0.268
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

Coupling lipid synthesis with nuclear envelope remodeling.
Barger et al. (2022)
5 more

1 mention without citation

Crystal structure of a lipin/Pah phosphatidic acid phosphatase.
Khayyo et al. (2020)