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EM structure of MPEG-1(L425K) pre-pore complex bound to liposome

Electron Microscopy
3.63Å resolution
PDB entry 6u2w coloured by chain, front view.
PDB entry 6u2w coloured by chain, side view.
PDB entry 6u2w coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexadecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage-expressed gene 1 protein
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Multimeric state: homo hexadecamer
Accessible surface area: 450578.77 Å2
Buried surface area: 75324.92 Å2
Dissociation area: 30,994.75 Å2
Dissociation energy (ΔGdiss): 59.57 kcal/mol
Dissociation entropy (TΔSdiss): 245.09 kcal/mol
Symmetry number: 16
PDBe Complex ID: PDB-CPX-173719

Macromolecules

Macrophage-expressed gene 1 protein
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 642 amino acids
Theoretical weight: 71.13 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q2M385 (Residues: 18-653; Coverage: 91%)
Gene name: MPEG1
Pfam: MAC/Perforin domain
InterPro:
Macrophage-expressed gene 1 protein in PDB entry 6u2w, assembly 1, front view.
Macrophage-expressed gene 1 protein in PDB entry 6u2w, assembly 1, side view.
Macrophage-expressed gene 1 protein in PDB entry 6u2w, assembly 1, top view.
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