Function and Biology

Crystal structure of recombinant class II fumarase from Schistosoma mansoni

Source organism: Schistosoma mansoni
Biochemical function: lyase activity
Biological process: malate metabolic process
Cellular component: mitochondrion

EC 4.2.1.2: Fumarate hydratase

Reaction catalysed:
(S)-malate = fumarate + H(2)O
Systematic name:
(S)-malate hydro-lyase (fumarate-forming)
Alternative Name(s):
  • (S)-malate hydro-lyase
  • Fumarase
  • L-malate hydro-lyase

Sequence families

Pfam Protein families (Pfam)
PF10415
Domain description: Fumarase C C-terminus
Occurring in:
  1. fumarate hydratase
The deposited structure of PDB entry 6u4o contains 4 copies of Pfam domain PF10415 (Fumarase C C-terminus) in fumarate hydratase. Showing 1 copy in chain B [auth A].

PF00206
Domain description: Lyase
Occurring in:
  1. fumarate hydratase
The deposited structure of PDB entry 6u4o contains 4 copies of Pfam domain PF00206 (Lyase) in fumarate hydratase. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR000362
Domain description: Fumarate lyase family
Occurring in:
  1. fumarate hydratase
IPR005677
Domain description: Fumarate hydratase, class II
Occurring in:
  1. fumarate hydratase
IPR018951
Domain description: Fumarase C, C-terminal
Occurring in:
  1. fumarate hydratase
IPR020557
Domain description: Fumarate lyase, conserved site
Occurring in:
  1. fumarate hydratase
IPR022761
Domain description: Fumarate lyase, N-terminal
Occurring in:
  1. fumarate hydratase
IPR008948
Domain description: L-Aspartase-like
Occurring in:
  1. fumarate hydratase
IPR024083
Domain description: Fumarase/histidase, N-terminal
Occurring in:
  1. fumarate hydratase