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NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation

Electron Microscopy
3.07Å resolution
PDB entry 6u5s coloured by chain, front view.
PDB entry 6u5s coloured by chain, side view.
PDB entry 6u5s coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutamate receptor 2
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Multimeric state: homo tetramer
Accessible surface area: 63783.35 Å2
Buried surface area: 9423.67 Å2
Dissociation area: 2,699.22 Å2
Dissociation energy (ΔGdiss): -7.49 kcal/mol
Dissociation entropy (TΔSdiss): 43.04 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148611

Macromolecules

Glutamate receptor 2
Chains: A, B, C, D
Length: 889 amino acids
Theoretical weight: 99.53 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-868; Coverage: 98%)
Gene names: GluA2, Glur2, Gria2
Pfam:
InterPro:
Glutamate receptor 2 in PDB entry 6u5s, assembly 1, front view.
Glutamate receptor 2 in PDB entry 6u5s, assembly 1, side view.
Glutamate receptor 2 in PDB entry 6u5s, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P19491  
1889100200300400500600700800
 
200400600800
UniProt
P19491
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