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Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846

X-ray diffraction
2.806Å resolution
PDB entry 6u6o coloured by chain, front view.
PDB entry 6u6o coloured by chain, side view.
PDB entry 6u6o coloured by chain, top view.
Source organism: Macaca mulatta
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 18879.8 Å2
Buried surface area: 3658.36 Å2
Dissociation area: 1,829.18 Å2
Dissociation energy (ΔGdiss): 20.03 kcal/mol
Dissociation entropy (TΔSdiss): 13.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-232258

Macromolecules

DH846 Fab heavy chain
Chain: H
Length: 228 amino acids
Theoretical weight: 24.22 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
InterPro:
DH846 Fab heavy chain in PDB entry 6u6o, assembly 1, front view.
DH846 Fab heavy chain in PDB entry 6u6o, assembly 1, side view.
DH846 Fab heavy chain in PDB entry 6u6o, assembly 1, top view.
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DH846 Fab light chain
Chain: L
Length: 213 amino acids
Theoretical weight: 23.2 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
InterPro:
DH846 Fab light chain in PDB entry 6u6o, assembly 1, front view.
DH846 Fab light chain in PDB entry 6u6o, assembly 1, side view.
DH846 Fab light chain in PDB entry 6u6o, assembly 1, top view.
Molecule details ›

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