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Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment reconstruction.

Electron Microscopy
4.2Å resolution
PDB entry 6ua2 coloured by chain, front view.
PDB entry 6ua2 coloured by chain, side view.
PDB entry 6ua2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexadecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inosine-5'-monophosphate dehydrogenase 2
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Multimeric state: homo hexadecamer
Accessible surface area: 154963.55 Å2
Buried surface area: 78344.08 Å2
Dissociation area: 3,944.47 Å2
Dissociation energy (ΔGdiss): -13.76 kcal/mol
Dissociation entropy (TΔSdiss): 64.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146108

Macromolecules

Inosine-5'-monophosphate dehydrogenase 2
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 519 amino acids
Theoretical weight: 56.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12268 (Residues: 1-514; Coverage: 100%)
Gene names: IMPD2, IMPDH2
Pfam:
InterPro:
Inosine-5'-monophosphate dehydrogenase 2 in PDB entry 6ua2, assembly 1, front view.
Inosine-5'-monophosphate dehydrogenase 2 in PDB entry 6ua2, assembly 1, side view.
Inosine-5'-monophosphate dehydrogenase 2 in PDB entry 6ua2, assembly 1, top view.
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