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Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction.

Electron Microscopy
3.84Å resolution
PDB entry 6uaj coloured by chain, front view.
PDB entry 6uaj coloured by chain, side view.
PDB entry 6uaj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inosine-5'-monophosphate dehydrogenase 2
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Multimeric state: homo octamer
Accessible surface area: 140905.14 Å2
Buried surface area: 83218.78 Å2
Dissociation area: 25,076.31 Å2
Dissociation energy (ΔGdiss): 260.58 kcal/mol
Dissociation entropy (TΔSdiss): 112.68 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-146110

Macromolecules

Inosine-5'-monophosphate dehydrogenase 2
Chains: A, B, C, D, E, F, G, H
Length: 519 amino acids
Theoretical weight: 56.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12268 (Residues: 1-514; Coverage: 100%)
Gene names: IMPD2, IMPDH2
Pfam:
InterPro:
Inosine-5'-monophosphate dehydrogenase 2 in PDB entry 6uaj, assembly 1, front view.
Inosine-5'-monophosphate dehydrogenase 2 in PDB entry 6uaj, assembly 1, side view.
Inosine-5'-monophosphate dehydrogenase 2 in PDB entry 6uaj, assembly 1, top view.
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