› 6ucf

X-ray diffraction
1.29Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209051 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6GMX0 (Residues: 23-235; Coverage: 100%)
Sequence domains:
N123-VRC34_pI4 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 8 amino acids
Theoretical weight: 733 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 512-519; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 38.42Å b: 86.434Å c: 128.657Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.182
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

3 review citations

Neutralizing Antibodies Targeting HIV-1 gp41.
Caillat et al. (2020)
2 more

2 mentions without citation

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Shen et al. (2020)
1 more