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Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2

Source organisms:
Biochemical function: extracellular matrix protein binding
Biological process: obsolete regulation of transforming growth factor beta activation
Cellular component: extracellular exosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01839
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 6ujb contains 3 copies of Pfam domain PF01839 (FG-GAP repeat) in Integrin alpha-V. Showing 3 copies in chain A.

PF07974
Domain description: EGF-like domain
Occurring in:
  1. Integrin beta-8
The deposited structure of PDB entry 6ujb contains 1 copy of Pfam domain PF07974 (EGF-like domain) in Integrin beta-8. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF00362
Domain description: Integrin beta chain VWA domain
Occurring in:
  1. Integrin beta-8
The deposited structure of PDB entry 6ujb contains 1 copy of Pfam domain PF00362 (Integrin beta chain VWA domain) in Integrin beta-8. Showing 1 copy in chain B.

PF17205
Domain description: Integrin plexin domain
Occurring in:
  1. Integrin beta-8
The deposited structure of PDB entry 6ujb contains 1 copy of Pfam domain PF17205 (Integrin plexin domain) in Integrin beta-8. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF00357
Domain description: Integrin alpha cytoplasmic region
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 6ujb contains 1 copy of Pfam domain PF00357 (Integrin alpha cytoplasmic region) in Integrin alpha-V. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF20806
Domain description: Integrin alpha Ig-like domain 3
Occurring in:
  1. Integrin alpha-V

PF20805
Domain description: Integrin alpha Ig-like domain 2
Occurring in:
  1. Integrin alpha-V

PF08441
Domain description: Integrin alpha Ig-like domain 1
Occurring in:
  1. Integrin alpha-V
The deposited structure of PDB entry 6ujb contains 1 copy of Pfam domain PF08441 (Integrin alpha) in Integrin alpha-V. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015812
Domain description: Integrin beta subunit
Occurring in:
  1. Integrin beta-8
IPR013519
Domain description: Integrin alpha beta-propellor
Occurring in:
  1. Integrin alpha-V
IPR000413
Domain description: Integrin alpha chain
Occurring in:
  1. Integrin alpha-V
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. C6D4 heavy chain Fab
  2. C6D4 light chain Fab
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. C6D4 heavy chain Fab
  2. C6D4 light chain Fab
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. C6D4 heavy chain Fab
  2. C6D4 light chain Fab
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. C6D4 heavy chain Fab
  2. C6D4 light chain Fab
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. C6D4 heavy chain Fab
  2. C6D4 light chain Fab
IPR032695
Domain description: Integrin domain superfamily
Occurring in:
  1. Integrin alpha-V
  2. Integrin beta-8
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. C6D4 heavy chain Fab
  2. C6D4 light chain Fab
IPR013517
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-V
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Integrin beta-8
IPR002369
Domain description: Integrin beta subunit, VWA domain
Occurring in:
  1. Integrin beta-8
IPR018184
Domain description: Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Occurring in:
  1. Integrin alpha-V
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. C6D4 light chain Fab
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Integrin beta-8
IPR013111
Domain description: EGF-like domain, extracellular
Occurring in:
  1. Integrin beta-8
IPR016201
Domain description: PSI domain
Occurring in:
  1. Integrin beta-8
IPR033760
Domain description: Integrin beta N-terminal
Occurring in:
  1. Integrin beta-8
IPR013649
Domain description: Integrin alpha, first immunoglubulin-like domain
Occurring in:
  1. Integrin alpha-V
IPR028994
Domain description: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-V

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