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STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 11

X-ray diffraction
1.93Å resolution
PDB entry 6ukx coloured by chain, front view.
PDB entry 6ukx coloured by chain, side view.
PDB entry 6ukx coloured by chain, top view.
Source organisms:
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Stimulator of interferon genes protein, Ubiquitin-like protein SMT3
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Multimeric state: homo dimer
Accessible surface area: 15470.12 Å2
Buried surface area: 3939.75 Å2
Dissociation area: 1,969.88 Å2
Dissociation energy (ΔGdiss): 17.52 kcal/mol
Dissociation entropy (TΔSdiss): 12.8 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171337

Macromolecules

Stimulator of interferon genes protein; Ubiquitin-like protein SMT3
Chains: A, B
Length: 300 amino acids
Theoretical weight: 34.46 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q12306 (Residues: 2-98; Coverage: 96%)
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
    • nullnull
Gene names: D9719.15, ERIS, MITA, SMT3, STING, STING1, TMEM173, YDR510W
Pfam:
InterPro:
Stimulator of interferon genes protein in PDB entry 6ukx, assembly 1, front view.
Stimulator of interferon genes protein in PDB entry 6ukx, assembly 1, side view.
Stimulator of interferon genes protein in PDB entry 6ukx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q12306   Q86WV6  
130020406080100120140160180200220240260280300
 
100200300MAHHHHHHGSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLTFLYDGIEIQADQTPEDLDMEDNDIIEAHREQIGGENLYFQSVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEV
UniProt
Q12306
Q86WV6
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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