› › Structure analysis

BRD4-BD1 in complex with the cyclic peptide 4.2_1

X-ray diffraction
2.2Å resolution
PDB entry 6ulv coloured by chain, front view.
PDB entry 6ulv coloured by chain, side view.
PDB entry 6ulv coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromodomain-containing protein 4 and peptide
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Multimeric state: hetero trimer
Accessible surface area: 13167.42 Å2
Buried surface area: 4575.44 Å2
Dissociation area: 1,079.05 Å2
Dissociation energy (ΔGdiss): -0.7 kcal/mol
Dissociation entropy (TΔSdiss): 11.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130151
Assembly 2
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Assembly Name: Bromodomain-containing protein 4 and peptide
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Multimeric state: hetero trimer
Accessible surface area: 13051.62 Å2
Buried surface area: 4130.09 Å2
Dissociation area: 904.37 Å2
Dissociation energy (ΔGdiss): 3.02 kcal/mol
Dissociation entropy (TΔSdiss): 11.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130151

Macromolecules

Bromodomain-containing protein 4
Chains: A, B, C, D
Length: 146 amino acids
Theoretical weight: 17.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 42-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Pfam: Bromodomain
InterPro:
Bromodomain-containing protein 4 in PDB entry 6ulv, assembly 1, front view.
Bromodomain-containing protein 4 in PDB entry 6ulv, assembly 1, side view.
Bromodomain-containing protein 4 in PDB entry 6ulv, assembly 1, top view.
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Cyclic peptide 4.2_3
Chains: E, G
Length: 16 amino acids
Theoretical weight: 2.1 KDa
Source organism: synthetic construct
Expression system: Not provided
Cyclic peptide 4.2_3 in PDB entry 6ulv, assembly 1, front view.
Cyclic peptide 4.2_3 in PDB entry 6ulv, assembly 1, side view.
Cyclic peptide 4.2_3 in PDB entry 6ulv, assembly 1, top view.
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