Function and Biology Details
Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase T1A, proteasome beta-subunit
- Nucleophile aminohydrolases, N-terminal
- Peptidase T1A, proteasome beta-subunit, archaeal
- Proteasome alpha subunit, archaeal
- Proteasome B-type subunit
- Proteasome, subunit alpha/beta
- Proteasome alpha-type subunit
- Proteasome alpha-subunit, N-terminal domain
4 more domains
Structure analysis Details
Assembly composition:
hetero 35-mer (preferred)
Assembly name:
Proteasome complex (preferred)
PDBe Complex ID:
PDB-CPX-150397 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Proteasome subunit beta
Molecule details ›
Chains: 1, 2, H, I, J, K, L, M, N, V, W, X, Y, Z
Length: 203 amino acids
Theoretical weight: 22.29 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
Sequence domains: Proteasome subunit
Length: 203 amino acids
Theoretical weight: 22.29 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
- Canonical:
P28061 (Residues: 9-211; Coverage: 96%)
Sequence domains: Proteasome subunit
Proteasome subunit alpha
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 227 amino acids
Theoretical weight: 25.13 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
Sequence domains:
Length: 227 amino acids
Theoretical weight: 25.13 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
- Canonical: P25156 (Residues: 7-233; Coverage: 97%)
Sequence domains:
Proteasome activator PA28 C-terminal domain-containing protein
Molecule details ›
Chains: O, P, Q, R, S, T, U
Length: 228 amino acids
Theoretical weight: 25 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia phage EcSzw-2
UniProt:
Length: 228 amino acids
Theoretical weight: 25 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia phage EcSzw-2
UniProt:
- Canonical: Q9U8G2 (Residues: 4-231; Coverage: 99%)
Proteasome subunit alpha
Molecule details ›
Chains: a, b, c, d, e, f, g
Length: 224 amino acids
Theoretical weight: 24.72 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
Sequence domains:
Length: 224 amino acids
Theoretical weight: 24.72 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
- Canonical: P25156 (Residues: 10-233; Coverage: 96%)
Sequence domains:
