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Allosteric coupling between alpha-rings of the 20S proteasome, 20S singly capped with a PA26/V230F

Electron Microscopy
3.4Å resolution
PDB entry 6utg coloured by chain, front view.
PDB entry 6utg coloured by chain, side view.
PDB entry 6utg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 35-mer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proteasome complex
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Multimeric state: hetero 35-mer
Accessible surface area: 261693.72 Å2
Buried surface area: 139575.75 Å2
Dissociation area: 13,330.84 Å2
Dissociation energy (ΔGdiss): 74.9 kcal/mol
Dissociation entropy (TΔSdiss): 36.19 kcal/mol
Symmetry number: 7
PDBe Complex ID: PDB-CPX-150397

Macromolecules

Proteasome subunit beta
Chains: 1, 2, H, I, J, K, L, M, N, V, W, X, Y, Z
Length: 203 amino acids
Theoretical weight: 22.29 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: P28061 (Residues: 9-211; Coverage: 96%)
Gene names: Ta0612, psmB
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta in PDB entry 6utg, assembly 1, front view.
Proteasome subunit beta in PDB entry 6utg, assembly 1, side view.
Proteasome subunit beta in PDB entry 6utg, assembly 1, top view.
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Proteasome subunit alpha
Chains: A, B, C, D, E, F, G
Length: 227 amino acids
Theoretical weight: 25.13 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: P25156 (Residues: 7-233; Coverage: 97%)
Gene names: Ta1288, psmA
Pfam:
InterPro:
Proteasome subunit alpha in PDB entry 6utg, assembly 1, front view.
Proteasome subunit alpha in PDB entry 6utg, assembly 1, side view.
Proteasome subunit alpha in PDB entry 6utg, assembly 1, top view.
Molecule details ›

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Proteasome activator PA28 C-terminal domain-containing protein
Chains: O, P, Q, R, S, T, U
Length: 228 amino acids
Theoretical weight: 25 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: Q9U8G2 (Residues: 4-231; Coverage: 99%)
Pfam: Proteasome activator PA28, C-terminal
InterPro:
Proteasome activator PA28 C-terminal domain-containing protein in PDB entry 6utg, assembly 1, front view.
Proteasome activator PA28 C-terminal domain-containing protein in PDB entry 6utg, assembly 1, side view.
Proteasome activator PA28 C-terminal domain-containing protein in PDB entry 6utg, assembly 1, top view.
Molecule details ›

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Proteasome subunit alpha
Chains: a, b, c, d, e, f, g
Length: 224 amino acids
Theoretical weight: 24.72 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: P25156 (Residues: 10-233; Coverage: 96%)
Gene names: Ta1288, psmA
Pfam:
InterPro:
Proteasome subunit alpha in PDB entry 6utg, assembly 1, front view.
Proteasome subunit alpha in PDB entry 6utg, assembly 1, side view.
Proteasome subunit alpha in PDB entry 6utg, assembly 1, top view.
Molecule details ›

Search similar proteins

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