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Anthrax toxin protective antigen channels bound to edema factor

Source organism: Bacillus anthracis
Biochemical function: toxin activity
Biological process: protein homooligomerization
Cellular component: host cell cytosol

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EC 4.6.1.1: Adenylate cyclase

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Systematic name:
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Alternative Name(s):
  • 3',5'-cyclic AMP synthetase
  • ATP diphosphate-lyase (cyclizing)
  • ATP pyrophosphate-lyase
  • Adenyl cyclase
  • Adenylyl cyclase
  • Adenylylcyclase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF20835
Domain description: Anthrax protective antigen, immunoglobulin-like domain
Occurring in:
  1. Protective antigen
The deposited structure of PDB entry 6uzd contains 7 copies of Pfam domain PF20835 (Anthrax protective antigen, immunoglobulin-like domain) in Protective antigen. Showing 1 copy in chain A.

PF17476
Domain description: Clostridial binary toxin B/anthrax toxin PA domain 3
Occurring in:
  1. Protective antigen
The deposited structure of PDB entry 6uzd contains 7 copies of Pfam domain PF17476 (Clostridial binary toxin B/anthrax toxin PA domain 3) in Protective antigen. Showing 1 copy in chain A.

PF17475
Domain description: Clostridial binary toxin B/anthrax toxin PA domain 2
Occurring in:
  1. Protective antigen
The deposited structure of PDB entry 6uzd contains 7 copies of Pfam domain PF17475 (Clostridial binary toxin B/anthrax toxin PA domain 2) in Protective antigen. Showing 1 copy in chain A.

PF03495
Domain description: Clostridial binary toxin B/anthrax toxin PA Ca-binding domain
Occurring in:
  1. Protective antigen
The deposited structure of PDB entry 6uzd contains 7 copies of Pfam domain PF03495 (Clostridial binary toxin B/anthrax toxin PA Ca-binding domain) in Protective antigen. Showing 1 copy in chain A.

PF07691
Domain description: PA14 domain
Occurring in:
  1. Protective antigen
The deposited structure of PDB entry 6uzd contains 7 copies of Pfam domain PF07691 (PA14 domain) in Protective antigen. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF20850
Domain description: Oedema factor (EF), alpha-helical domain
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
The deposited structure of PDB entry 6uzd contains 2 copies of Pfam domain PF20850 (Oedema factor (EF), alpha-helical domain) in Calmodulin-sensitive adenylate cyclase. Showing 1 copy in chain H.

PF03497
Domain description: Anthrax toxin LF subunit
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
The deposited structure of PDB entry 6uzd contains 2 copies of Pfam domain PF03497 (Anthrax toxin LF subunit) in Calmodulin-sensitive adenylate cyclase. Showing 1 copy in chain H.

PF07737
Domain description: Anthrax toxin lethal factor, N- and C-terminal domain
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
The deposited structure of PDB entry 6uzd contains 2 copies of Pfam domain PF07737 (Anthrax toxin lethal factor, N- and C-terminal domain) in Calmodulin-sensitive adenylate cyclase. Showing 1 copy in chain H.

InterPro InterPro annotations
IPR003896
Domain description: Bacterial exotoxin B
Occurring in:
  1. Protective antigen
IPR003541
Domain description: Anthrax toxin, lethal/endema factor
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
IPR011658
Domain description: PA14 domain
Occurring in:
  1. Protective antigen
IPR027441
Domain description: Protective antigen, domain 4
Occurring in:
  1. Protective antigen
IPR035331
Domain description: Clostridial binary toxin B/anthrax toxin PA, domain 3
Occurring in:
  1. Protective antigen
IPR027439
Domain description: Protective antigen, heptamerisation domain
Occurring in:
  1. Protective antigen
IPR037149
Domain description: Protective antigen, heptamerisation domain superfamily
Occurring in:
  1. Protective antigen
IPR035088
Domain description: Protective antigen, Ca-binding domain
Occurring in:
  1. Protective antigen
IPR037524
Domain description: PA14/GLEYA domain
Occurring in:
  1. Protective antigen
IPR037017
Domain description: Anthrax toxin, edema factor, central domain superfamily
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
IPR005165
Domain description: Anthrax toxin, edema factor, central
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
IPR035099
Domain description: Anthrax toxin, edema factor, C-terminal
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
IPR047568
Domain description: Anthrax toxin lethal factor-like domain
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase
IPR014781
Domain description: Anthrax toxin, lethal/endema factor, N-/C-terminal
Occurring in:
  1. Calmodulin-sensitive adenylate cyclase

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