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Structure of TrkH-TrkA in complex with ADP

X-ray diffraction
3.53Å resolution
PDB entry 6v4k coloured by chain, front view.
PDB entry 6v4k coloured by chain, side view.
PDB entry 6v4k coloured by chain, top view.
Source organism: Vibrio parahaemolyticus
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Trk system potassium uptake protein TrkH and Trk system potassium uptake protein TrkA
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Multimeric state: hetero octamer
Accessible surface area: 150104.53 Å2
Buried surface area: 24522.2 Å2
Dissociation area: 3,652.53 Å2
Dissociation energy (ΔGdiss): -5.73 kcal/mol
Dissociation entropy (TΔSdiss): 32.62 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-183337

Macromolecules

Trk system potassium uptake protein TrkH
Chains: A, B, C, D
Length: 485 amino acids
Theoretical weight: 53.1 KDa
Source organism: Vibrio parahaemolyticus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q87TN7 (Residues: 1-485; Coverage: 100%)
Gene names: VP0032, trkH
Pfam: Cation transport protein
InterPro:
Trk system potassium uptake protein TrkH in PDB entry 6v4k, assembly 1, front view.
Trk system potassium uptake protein TrkH in PDB entry 6v4k, assembly 1, side view.
Trk system potassium uptake protein TrkH in PDB entry 6v4k, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q87TN7  
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Trk system potassium uptake protein TrkA
Chains: E, F, G, H
Length: 458 amino acids
Theoretical weight: 50.19 KDa
Source organism: Vibrio parahaemolyticus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q87KD2 (Residues: 1-458; Coverage: 100%)
Gene name: VP3045
Pfam:
InterPro:
Trk system potassium uptake protein TrkA in PDB entry 6v4k, assembly 1, front view.
Trk system potassium uptake protein TrkA in PDB entry 6v4k, assembly 1, side view.
Trk system potassium uptake protein TrkA in PDB entry 6v4k, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q87KD2  
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