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HLA-B*15:02 complexed with a synthetic peptide

X-ray diffraction
2.334Å resolution
PDB entry 6viu coloured by chain, front view.
PDB entry 6viu coloured by chain, side view.
PDB entry 6viu coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18791.07 Å2
Buried surface area: 4867.05 Å2
Dissociation area: 811.37 Å2
Dissociation energy (ΔGdiss): 10.55 kcal/mol
Dissociation entropy (TΔSdiss): 7.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-123511

Macromolecules

Ig-like domain-containing protein
Chain: A
Length: 276 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: F4NBQ8 (Residues: 25-300; Coverage: 88%)
Gene name: HLA-B
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6viu, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6viu, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6viu, assembly 1, top view.
PDBe-KB: UniProt Coverage View: F4NBQ8  
127620406080100120140160180200220240260
 
100200
UniProt
F4NBQ8
Chains
Domains
Secondary structure
Ligand binding sites
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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
Beta-2-microglobulin in PDB entry 6viu, assembly 1, front view.
Beta-2-microglobulin in PDB entry 6viu, assembly 1, side view.
Beta-2-microglobulin in PDB entry 6viu, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61769  
1100102030405060708090100
 
50100MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt
P61769
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
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THR-VAL-ALA-ALA-SER-GLY-HIS-SER-TYR
Chain: C
Length: 9 amino acids
Theoretical weight: 893 Da
Source organism: synthetic construct
Expression system: Not provided
THR-VAL-ALA-ALA-SER-GLY-HIS-SER-TYR in PDB entry 6viu, assembly 1, front view.
THR-VAL-ALA-ALA-SER-GLY-HIS-SER-TYR in PDB entry 6viu, assembly 1, side view.
THR-VAL-ALA-ALA-SER-GLY-HIS-SER-TYR in PDB entry 6viu, assembly 1, top view.
19123456789
 
246810TVAASGHSY
Chains
Chain C (auth C)
Interaction interfaces
Molecule details ›

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