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Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin

Electron Microscopy
3.02Å resolution
PDB entry 6vks coloured by chain, front view.
PDB entry 6vks coloured by chain, side view.
PDB entry 6vks coloured by chain, top view.
Source organism: Neisseria gonorrhoeae
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Efflux pump membrane transporter
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Multimeric state: homo trimer
Accessible surface area: 126602.49 Å2
Buried surface area: 31325.24 Å2
Dissociation area: 7,911.31 Å2
Dissociation energy (ΔGdiss): 67.51 kcal/mol
Dissociation entropy (TΔSdiss): 18.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-177066

Macromolecules

Efflux pump membrane transporter
Chains: A, B, C
Length: 1049 amino acids
Theoretical weight: 112.04 KDa
Source organism: Neisseria gonorrhoeae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5F725 (Residues: 1-1049; Coverage: 98%)
Gene name: NGO_1364
Pfam: AcrB/AcrD/AcrF family
InterPro:
Efflux pump membrane transporter in PDB entry 6vks, assembly 1, front view.
Efflux pump membrane transporter in PDB entry 6vks, assembly 1, side view.
Efflux pump membrane transporter in PDB entry 6vks, assembly 1, top view.
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