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T cell receptor-p53-HLA-A2 complex

X-ray diffraction
2.46Å resolution
PDB entry 6vrn coloured by chain, front view.
PDB entry 6vrn coloured by chain, side view.
PDB entry 6vrn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 36711.4 Å2
Buried surface area: 10460.04 Å2
Dissociation area: 1,001.97 Å2
Dissociation energy (ΔGdiss): -5.66 kcal/mol
Dissociation entropy (TΔSdiss): 13.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-231544

Macromolecules

Ig-like domain-containing protein
Chain: A
Length: 293 amino acids
Theoretical weight: 33.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A140T913 (Residues: 25-299; Coverage: 79%)
Gene name: HLA-A
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6vrn, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6vrn, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6vrn, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A0A140T913  
129320406080100120140160180200220240260280
 
100200
UniProt
A0A140T913
Chains
Domains
Secondary structure
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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
Beta-2-microglobulin in PDB entry 6vrn, assembly 1, front view.
Beta-2-microglobulin in PDB entry 6vrn, assembly 1, side view.
Beta-2-microglobulin in PDB entry 6vrn, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61769  
1100102030405060708090100
 
50100MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt
P61769
Chains
Domains
Secondary structure
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T-cell receptor 38-10, alfa chain
Chain: D
Length: 212 amino acids
Theoretical weight: 23.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
T-cell receptor 38-10, alfa chain in PDB entry 6vrn, assembly 1, front view.
T-cell receptor 38-10, alfa chain in PDB entry 6vrn, assembly 1, side view.
T-cell receptor 38-10, alfa chain in PDB entry 6vrn, assembly 1, top view.
121220406080100120140160180200
 
50100150200
Chains
Chain C (auth D)
Domains
Secondary structure
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TCR repeptor 38-10, beta chain
Chain: E
Length: 245 amino acids
Theoretical weight: 27.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
TCR repeptor 38-10, beta chain in PDB entry 6vrn, assembly 1, front view.
TCR repeptor 38-10, beta chain in PDB entry 6vrn, assembly 1, side view.
TCR repeptor 38-10, beta chain in PDB entry 6vrn, assembly 1, top view.
124520406080100120140160180200220240
 
100200
Chains
Chain D (auth E)
Domains
Secondary structure
Flexibility predictions
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Cellular tumor antigen p53
Chain: P
Length: 9 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 168-176; Coverage: 2%)
Gene names: P53, TP53
Cellular tumor antigen p53 in PDB entry 6vrn, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 6vrn, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 6vrn, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P04637  
19123456789
 
246810HMTEVVRHC
UniProt
P04637
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