› 6vwh

Electron Microscopy
4.26Å resolution

Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Released:
DOI: 10.2210/pdb6vwh/pdb
PDB entry 6vwh coloured by chain, front view.
PDB entry 6vwh coloured by chain, side view.
PDB entry 6vwh coloured by chain, top view.
Source organisms:
Primary publication:
How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
OpenAccess logo Structure 28 786-798.e6 (2020)
PMID: 32459985
Related structures: EMD-21416

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136505 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General control transcription factor GCN4; Insulin-like growth factor 1 receptor alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 952 amino acids
Theoretical weight: 108.94 KDa
Source organisms: Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08069 (Residues: 31-935; Coverage: 68%)
  • Canonical: P03069 (Residues: 249-281; Coverage: 12%)
Gene names: AAS101, AAS3, ARG9, GCN4, IGF1R, YEL009C
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.26Å
Relevant EMDB volumes: EMD-21416
Expression system: Cricetulus griseus

Quick links

Citations

4 review citations

Insulin-like growth factors: Ligands, binding proteins, and receptors.
LeRoith et al. (2021)
3 more

2 mentions without citation

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators.
Turvey et al. (2022)
1 more