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Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Electron Microscopy
4.26Å resolution
PDB entry 6vwh coloured by chain, front view.
PDB entry 6vwh coloured by chain, side view.
PDB entry 6vwh coloured by chain, top view.
Source organisms:
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: General control transcription factor GCN4, Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: homo dimer
Accessible surface area: 31861.46 Å2
Buried surface area: 1135.06 Å2
Dissociation area: 567.53 Å2
Dissociation energy (ΔGdiss): -6.32 kcal/mol
Dissociation entropy (TΔSdiss): 12.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136505

Macromolecules

General control transcription factor GCN4; Insulin-like growth factor 1 receptor alpha chain
Chains: A, B
Length: 952 amino acids
Theoretical weight: 108.94 KDa
Source organisms: Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08069 (Residues: 31-935; Coverage: 68%)
  • Canonical: P03069 (Residues: 249-281; Coverage: 12%)
    • nullnull
Gene names: AAS101, AAS3, ARG9, GCN4, IGF1R, YEL009C
Pfam:
InterPro:
General control transcription factor GCN4 in PDB entry 6vwh, assembly 1, front view.
General control transcription factor GCN4 in PDB entry 6vwh, assembly 1, side view.
General control transcription factor GCN4 in PDB entry 6vwh, assembly 1, top view.
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