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The crystal structure of the 2009/H1N1/California PA endonuclease wild type bound to DNA oligomer TAGC (cleaved TTAGCATT, 5mM overnight DNA soak)

X-ray diffraction
1.92Å resolution
PDB entry 6whm coloured by chain, front view.
PDB entry 6whm coloured by chain, side view.
PDB entry 6whm coloured by chain, top view.
Source organism: Influenza A virus
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein PA-X and DNA
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Multimeric state: hetero dimer
Accessible surface area: 9328.46 Å2
Buried surface area: 2090.94 Å2
Dissociation area: 539.83 Å2
Dissociation energy (ΔGdiss): 6.95 kcal/mol
Dissociation entropy (TΔSdiss): 7.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-111580

Macromolecules

Protein PA-X
Chain: A
Length: 197 amino acids
Theoretical weight: 23.15 KDa
Source organism: Influenza A virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C6H0Y9 (Residues: 1-50, 74-196; Coverage: 42%)
Gene name: PA
Pfam: Influenza RNA-dependent RNA polymerase subunit PA
InterPro:
Protein PA-X in PDB entry 6whm, assembly 1, front view.
Protein PA-X in PDB entry 6whm, assembly 1, side view.
Protein PA-X in PDB entry 6whm, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(P*TP*AP*GP*C)-3')
Representative chains: B
Length: 8 nucleotides
Theoretical weight: 2.42 KDa
DNA (5'-D(P*TP*AP*GP*C)-3') in PDB entry 6whm, assembly 1, front view.
DNA (5'-D(P*TP*AP*GP*C)-3') in PDB entry 6whm, assembly 1, side view.
DNA (5'-D(P*TP*AP*GP*C)-3') in PDB entry 6whm, assembly 1, top view.
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